Mercy Hospital South
1873
St. Anthony's tradition of Catholic health care begins in 1873, when the Franciscan Sisters of Germany open St. Boniface Hospital in South St. Louis. In the years that follow, Pius Hospital opens in North St. Louis, followed by "little St. Anthony's" in South St. Louis.
1900
A new St. Anthony’s Hospital opens at Grand Boulevard and Chippewa Street in South St. Louis. The Franciscan Sisters care for patients in 125 private rooms and two large wards, providing care to those in need regardless of creed or ability to pay.
1946
When a major polio epidemic reaches St. Louis, few hospitals are equipped to care for patients with the disease. St. Anthony's responds by becoming a leading polio treatment center in the Midwest, caring for more than 100 patients a day.
1962
As the St. Louis region grows westward, the Franciscan Sisters begin planning for a new hospital in St. Louis County. They purchase a peach grove from local farmer Fred Bender and select the site for the future St. Anthony's campus.
1967
The Franciscan Sisters transfer ownership and governance of the hospital to a lay board, beginning a new chapter in St. Anthony's leadership.
1975
On March 23, St. Anthony's Medical Center opens at its current location in South St. Louis County.
Volunteers from Scott Air Force Base's Aeromedical Staging Facility help move patients from the former St. Anthony's Hospital at Grand and Chippewa to the new campus.
1977
Hyland Center opens to provide treatment for addition and dependency, followed by St. Anthony's Psychiatric Center. The Hyland Adolescent Center later expands behavioral health services for young people who need specialized support.
1999
The Fern and Russell de Greeff Hospice House opens as the first nonprofit residential hospice center in the Midwest. Patients with terminal illnesses receive pain management, comfort care and support in a home-like setting.
2008
St. Anthony's Heart & Surgical Center opens in partnership with local cardiologists. The dedicated patient care tower brings advanced heart and surgical services together for patients across the region.
2017
On June 1, 2017, St. Anthony’s Medical Center aligns with Mercy.
2018
St. Anthony’s becomes Mercy Hospital South, Mercy's fifth acute care hospital in the St. Louis area.
The transition brings together two Catholic health care organizations with a shared commitment to compassionate service for patients and communities.
2020
The David M. Sindelar Cancer Center opens on the Mercy Hospital South campus. The two-story, 78,000-square-foot center brings cancer services together in one location, including infusion therapy, radiation oncology, imaging, laboratory services, integrative medicine and spiritual support.
2021
A renovation of the hospital's fourth floor creates 15 new labor, delivery, recovery and postpartum suites. Larger rooms give families more space throughout labor, birth and recovery, while updated operating rooms support maternity care.
2022
Mercy Rehabilitation Hospital South opens as a 50-bed inpatient rehabilitation hospital. The facility cares for adults recovering from neurological conditions, brain and spinal cord injuries and other serious illnesses or injuries.
2025
Construction begins on a major expansion and redesign of the emergency department to meet the growing needs of the community.
The $75 million project expands the emergency department from 39,000 to 65,000 square feet and adds more patient rooms, larger trauma bays, a dedicated behavioral health area and redesigned care spaces to improve visibility and workflow.
The project is expected to be completed in 2027.
